Antenatal Prophylaxis - Free Video CPD for Obs, Gynae & Midwives

Health Professional Academy
Delivery Method: eLearning

Antenatal prophylaxis with anti-D immunoglobulin: An ongoing success story


Administration of anti-D immunoglobulin to Rhesus D (RhD)- negative pregnant women reduces the morbidity and mortality associated with haemolytic disease of the fetus and newborn (HDFN). NICE advocates non-invasive prenatal testing (NIPT) to guide the use of anti-D immunoglobulin and this is gradually being rolled out across the UK.


After studying this module you should:

  • Understand the biological basis of RhD incompatibility.
  • Appreciate when fetal blood may enter the maternal circulation, thereby ‘sensitising’ the woman’s immune system to produce anti-D antibodies.
  • Be aware of when and how anti-D prophylaxis should be administered, and the role of NIPT in guiding its use.


  • Read the clinical review
  • Complete the online assessment
  • Receive CPD certificate


Reviewed by: Jayne Marshall Foundation Professor of Midwifery at University of Leicester FRCM, PFHEA, PhD, MA, PGCEA, ADM, RM, RGN

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